克莱尔的父亲杰克·麦克劳德在妻子和儿子难产去世后，与城里女孩露丝·西尔弗曼结婚。苔丝便是这段风雨飘摇却短暂的感情的结晶。两个女孩从小就非常亲密，但当露丝带着五岁的苔丝回到城里时，两人便分开了。二十年后，杰克突然去世，他的女儿们各自继承了抵押贷款沉重的“德罗弗跑”一半的股份。苔丝的母亲最近因乳腺癌去世，她回到“德罗弗跑”希望能套现，在城里开一家咖啡馆，但却失望地发现，她的财务状况并不乐观，姐姐也公开表示不满。
ATimetoHeal-TheteamiscalledouttoNorthernIrelandtoinvestigatethebodiesoftwomenkill...
4400weretaken.4400werereturned.Eachhasauniqueability.Oneamongthemhasamessage.Anyonecanbecomeextraordinary.Theriskisgreat.Butsoaretherewards.Andnowthere’snoturningbackTheworldwillhavetodealwithus.一个阳光普照的好日子，Tom站在自己的厨房里喝着咖啡。他看了看表，叫Kyle赶快下楼来，说他们快迟到了。Kyle笑盈盈地冲下来，父子俩这辈子也没这么开心过。Tom挥了挥手，桌上的车钥匙飞到了他的手中－－难道Tom也喝下Promicin并产生了超能力？4400中心的广场上已经聚集了不少人，其中许多都是我们的老熟人：Diana、Maia、Marco、KevinBurkoff、TessDo...
Will&Gracearebestfriends.WillisagaylawyerandGraceisastraightinteriordesigner.TheybothliveinNewYork.Graceisengagedtoarealjerk,butwhenthatrelationshipfallsapart,shemovesinwithWill.ThisisonlysupposedtobeuntilGracefindsaplaceofherown,butsheandWillendupwitheachotheraspermanentroommates.AlsointhecastareJack,Will’sflamboyantgayfriendandKaren,Graces’secretary/assistantwhodoesn’treallyneedtoworkbecauseshemarriedmoneyseveraltimes.
WhenaboatcarryingillegalpassengersisfoundcrashedintheThames,theteaminvestigate.
Followthestoryofa30-year-oldwomanwho,whenfeelingdissatisfiedwithhermarriageandfamilylife,findsherselfsentbackintime10yearsfollowingalunareclipse.
Twocouplesandmeijubar.nettheirsinglefriend,allatdifferentstagesintheirrelationships,dealwiththecomplicationsofdating,commitmentandmarriage.
